I believe such things do exist as do reversed qwerty keyboards- that wouldn't bother me as I can type two handed anyway, but one with the function blocks on the left would be useful.

My best ever 'left handed' investment was my set of left handed kitchen knives It really does make that much difference. :o)

Oddly, I play diatonic accordeon (aka melodeon) and I play that right handed (when I first started years back, I took the view that the bass end was the really complex bit) although I play mandolin left handed.